Knockout Tested Rabbit recombinant monoclonal CD130 (gp130) antibody [ EPR21732]. Validated in WB, ELISA and tested in Human, Recombinant fragment.

2011-09-01 · gp130 (also known as CD130) is expressed in almost all organs, including heart, kidney, spleen, liver, lung, placenta, and brain, and targeted deletion of the gp130 gene in mice results in embryonic lethality at day 12.5 .

Members of this family have been shown to enhance the survival of migratory (E10.5) or postmigratory (E12.5) murine primordial germ cells (PGCs) in culture; however, it is uncertain what role these cytokines play during PGC development in vivo. 16193 Ensembl ENSG00000136244 ENSMUSG00000025746 UniProt P05231 P08505 RefSeq (mRNA) NM_000600 NM_001318095 NM_001371096 NM_031168 NM_001314054 RefSeq (protein) NP_000591 NP_001305024 NP_001358025 NP_001300983 NP_112445 Location (UCSC) Chr 7: 22.73 – 22.73 Mb Chr 5: 30.01 – 30.02 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin 6 (IL-6) is an interleukin that acts as Gp130 engagement leads to activation of Src and JAK/Tyk tyrosine kinases, as well as the STAT family of transcription factors (4, 5). IL-6 is the prototypic gp130-cytokine and binds the gp130 receptor through three conserved epitopes (sites I, II, and III), of which site III is unique to gp130-cytokines (6–9). GP130 is a signal-transducing subunit shared by the receptors for the IL-6 family of cytokines (1-3). The binding of a ligand to its receptor induces the dimerization of GP130, leading to activation of the Jak tyrosine kinase and to tyrosine phosphorylation of GP130. The cytokine receptor gp130 is the shared signalling subunit of the IL-6-type cytokines.

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gp130 deletion in gp130 is a ubiquitously expressed, signal‐transducing receptor that forms part of the receptor complex for several cytokines, including IL‐6, IL‐11, IL‐27, leukemia inhibitory factor, OSM, CNTF, cardiotrophin 1, and cardiotrophin‐like cytokine . gp130 was described initially in mice as a membrane‐bound glycoprotein, absent on Johana & Narquoise - Geispolsheim - GP130 GP130-KO cells transfected with GP130-p.N404Y were unable to up-regulate fibrinogen after stimulation with IL-6, whereas transfection of GP130-WT restored the response . This finding suggests that a delayed or absent acute-phase response as a critical innate immune reaction toward bacterial infection contributes to the complex immunodeficiency in P1. 5 Mar 2021 CD130 · GP130 · Gp130 Of The Rheumatoid Arthritis Antigenic Peptide-Bearing Soluble Form · Interleukin 6 Signal Transducer (Gp130, Oncostatin  Western Blotting Image 1: GP130 Antibody. Western blot analysis of extracts from NIH/3T3, PC12, COS and HeLa cells, using GP130 Antibody. 1/1 Image  8 Jan 2020 The gene IL6ST encodes GP130, the common signal transducer of the IL-6 cytokine family consisting of 10 cytokines.

The molecular cloning of human gp130cDNA was reported in 1990 (database accession, M57230). Macrophage recruitment is essential for heart regeneration through the secretion of OSM, which promotes cardiomyocyte proliferation. As the coreceptor of OSM, gp130 activation is sufficient to promote cardiomyocyte proliferation by activating Yap through Src during heart regeneration.

2001-03-16

Gp130, the common signal transducing receptor component shared by the functional receptor complexes of the IL-6 family of cytokines, belongs to the classI cytokine receptor family. Binding of IL-6 or IL-11 to either the membrane-anchored or soluble IL-6 R or IL-11 R, respectively, initiates the association of IL-6 R (IL-11 R) with gp130.

2021-03-26

655 kr. Winfields Outdoors Logotyp. Intressant nog detekterades gp130-associerad SHP-2-fosforylering i de IL-6-inducerade CESS-cellerna men inte myelomcellinjer. Uppgifterna visar en mycket  allmänt förekommande signalomvandlande glykoprotein 130 (gp130) och signalomvandlare och -transkriptionsaktiverare 3 (Signal Transducer and Activator,  Andra gener i denna region innefattar Ccnb1 och Ccnh, liksom Il6st (gp130), IL6st gp130, Pi3k p85a och Ras GAP i karcinom jämfört med normala körtlar  Cochet gp130. 2012. Backhoe.

Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists. Production of recombinant gp130‐RAPS by baculovirus‐infected insect cells. A, Production of gp130‐RAPS by insect cells was confirmed by immunofluorescence staining. Noninfected (top) and infected (bottom) Sf9 cells were fixed, incubated with a specific anti‐NIASF antibody (Mab529), and visualized using a fluorescein isothiocyanate–conjugated anti‐mouse antibody. gp130 is a ubiquitously expressed, signal‐transducing receptor that forms part of the receptor complex for several cytokines, including IL‐6, IL‐11, IL‐27, leukemia inhibitory factor, OSM, CNTF, cardiotrophin 1, and cardiotrophin‐like cytokine . gp130 was described initially in mice as a membrane‐bound glycoprotein, absent on Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors.It forms one subunit of the type I cytokine receptor within the IL-6 receptor family.
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The 'lollipop plot' above illustrates recurrent (observed in 3 or more out of 4440 TCGA tumor samples from 15 cancer types) and therefore potentially oncogenic missense mutations (click on 'Show Cancer Mutations'). Although gp130 and its dimer partners possess no intrinsic tyrosine kinase domain, the dimerization of gp130 leads to activation of associated cytoplasmic tyrosine kinases and subsequent modification of transcription factors. This paper reviews recent progress in the study of the interleukin-6 family of cytokines and gp130. 2015-06-01 · Several soluble forms of gp130 occur naturally in the human blood, which are generated by differential mRNA splicing and alternative polyadenylation . These sgp130 variants contain different numbers of the six extracellular domains of gp130 and differ in their efficiency to inhibit IL-6 trans-signaling as well as their biological half-life.

Cytokine Receptor  Here, we investigate the cellular localization, regulation, and possible function of two IL-6 receptors (IL-6Ralpha and gp130) in mouse and human fallopian  Sökning: "gp130". Visar resultat 1 - 5 av 13 avhandlingar innehållade ordet gp130. 1.
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Original Derbi Kühlerschlauch MULHACEN GP130 (00N03800021) Kühlerschlauch MULHACEN GP130. 16,05 EUR. inkl. 0% moms. exkl. frakt 

Previous studies have identified  Absence of GP130 cytokine receptor signaling causes extended Stüve-Wiedemann syndrome. / Chen, Yin Huai; Grigelioniene, Giedre; Newton, Phillip T.;  Expansor GP130. 339 kr. Denna produkt är tyvärr slut i lager. Klicka här för att se liknande produkter.

Gp130/JAK/STAT Pathway Model Report { Generated by the Bio-PEPA Workbench {Maria Luisa Guerriero December 16, 2008 1 Bio-PEPA model bind gl l 1 = [k 1 gp130 LIF LIFR]

NEDD4L is reduced in the epidermis of psoriasis patients and negatively correlates with GP130 and p‐STAT3 Gp130 −/− embryos, which are generated by heterozygous crossing, also die between day 13 and term due to abnormal cardiac development . Therefore, although LIF binds LIFR and recruits GP130, the definitive role of LIFR and GP130 in implantation remains uncertain. gp130 antibodies were obtained from Cell Signaling Technology (Frankfurt am Main, Germany). 2.2 Cell proliferation assay L3.6plandAsPC-1cellswereseededin96-well plates(5,000 cells/well) and allowed to grow overnight. Next, cells were incubated with raloxifene in serum-free medium at 37 °C for 48 hours. Cell proliferation was determined using a Bazedoxifene as a novel GP130 inhibitor for Colon Cancer therapy Jia Wei1,2, Ling Ma2, Yi-Hui Lai3, Ruijie Zhang2, Huameng Li4, Chenglong Li5 and Jiayuh Lin2* Abstract Background: Interleukin-11 (IL-11), a dominant IL-6 family cytokine, is involved in tumorigenesis, tumor progression and differentiation in colon cancer cells. 2020-07-27 · To further explore the role of gp130 in heart regeneration, we generated gp130 fl/fl mice, in which the 5′LoxP element was inserted into intron 16 to 17 and the 3′LoxP element into downstream of 3′-untranslated region; and conditional ablation of gp130 in cardiomyocytes was achieved by crossing Myh6-MerCreMer mice with gp130 fl/fl mice (Myh6-gp130 −/−) .

frakt. 655 kr. Winfields Outdoors Logotyp.